DNA Structure & Function

Inside the case file

Give your biology students a genetics review they'll actually lean into. This printable DNA Structure & Function Science Mystery for Grades 8–10 (a solid refresher for 11–12) wraps DNA structure, replication, protein synthesis, and mutations inside a science-detective case — no prep, no lab.

Careful reading is the key — each text-based answer knocks a suspect off the list until only the culprit stands. Nothing to prep or laminate.

Quick Details

Grade Levels: Grades 8–10 (great review for 11–12)
Format: Printable PDF (35 pages)
Resource Type: Science Mystery worksheets
Reading Skills: Nonfiction science comprehension, text evidence, cause and effect, and science vocabulary
Science Standards: Supports NGSS HS-LS1-1 and HS-LS3-1 (structure and function; inheritance)
Tech Needed: None — no apps, locks, passwords, or student logins required

The Case

Something has gone wrong at the molecular level, and a line-up of suspects is waiting. The only way to crack the case is to read closely about DNA — its structure, replication, protein synthesis, and mutations — using every comprehension answer as a clue to rule a suspect out, until just one explanation fits the evidence.

How the Science Mystery Works

Students work as Science Detectives, reading about DNA structure and function and clearing a suspect with each text-based answer until the culprit is all that's left. The answers are all in the passage.

What's Included

• A "You are a detective" case-file page that sets the scene and the mission
• An engaging science reading passage on DNA structure, replication, protein synthesis, and mutations
• Multiple-choice comprehension questions (all answers found in the text)
• Open-ended written response questions
• A suspect line-up page for eliminating suspects one clue at a time
• A science vocabulary word search and extension activities for early finishers
• A full answer key
• Color and black-and-white versions
• Print-and-go PDF format

Skills Covered

• Reading and understanding nonfiction science text
• Finding and using text evidence
• DNA structure and the double helix
• DNA replication, protein synthesis, and mutations
• Cause and effect and drawing conclusions from evidence
• Science vocabulary in context
• Logic, reasoning, and critical thinking

Best Used For

• Genetics, DNA, and molecular-biology units
• NGSS-aligned review and science literacy
• Biology reading comprehension and sub plans
• Science centers, test prep, and small groups
• Homeschool science